Publications

2011 PNAS: Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques2011 PNAS: Supporting Information
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2011 Vaccine: Dry Powder Measles vaccine: Particle deposition, virus replication, and immune response in cotton rats following inhalation  
2009 CIRES/Aktiv-Dry Poster - Unit Dose Packaging and Devlivery of Inhalable and Injectable Antibiotics for TB Treatment2009 Aktiv-Dry Poster - Creation of Inhalable Dry Powder Vaccine and Pharmaceutical Aerosols - AAPS2009 Sievers Gates lecture in Arusha
Abstract - Are Unit-Dose Dry Powder Vaccines Intrinsically Safer than Liquid Vaccines?Abstract - Unit Dose Packaging and Delivery of Inhalable and Injectable Antibiotics for TB TreatmentWinston Lecture - Safer, Needle-Free, Unit-Dose, Inhalable Dry Powder Vaccines - 2009
2009 Aespironics/Aktiv-Dry Poster - Affordable Needle-Free Vaccination Technology for Low Resources SettingCIRES/Aktiv-Dry 2009 Poster - Inhalable Mircoparticles of TB Antibiotics Mady by CAN-BDAktiv-Dry Poster - Inhalable Dry Powder Aerosol Attenuated Live Virus Measles Vaccine
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Preparation of Proteins, Vaccines, and Pharmaceuticals using Supercritical or Near-Critical Fluids
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2006 Abstract of Micronization of Stabilized Vaccines, Antibiotics and Antivirals
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2008 Poster on Drying Nucleotides by CAN-BD
SELECTED PUBLICATIONS

"Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-Critical Fluids", S.P. Cape, J.A. Villa, E.T.S. Huang, T-H Yang, J.F. Carpenter, R.E. Sievers, Pharmaceutical Research, DOI: 10.1007/s11095-008-9575-6

"Challenges of Developing a Stable Dry Powder Live Viral Vaccine", R.E. Sievers, S.P. Cape, K.O. Kisich, D.J.Bennett, C.S. Braun, J.L. Burger, J.A. Best, D.H. McAdams, N.A. Wolters, B.P. Quinn, J.A. Searles, D.M. Krank, P. Pathak, P.A. Bhagwat, L.G. Rebits, Respiratory Drug Delivery 2008, Vol. 2 Dalby, R.N. et al. (eds.) pp. XX - YY, Davis Healthcare International Publishing, LLC, River Grove, IL.

“Synthesis of Composite Microparticles with a Mixing Cross.“ Villa, J.A., Huang, E.T.S., Cape, S.P., Sievers, R.E, Aerosol Science and Technology, 39(6), 473-484 (2005).

“Stabilization of Measles Virus for Vaccine Formulation.” Kissmann, J., Ausar, S.F., Randolph, A., Braun, C., Cape, S.P., Sievers, R.E., Federspiel, M.J., Middaugh, C.R., Human Vaccine. March 7; 4(5). 2008

"The PuffHaler™: A Simple Active DPI with a Pressure Release Valve Disperser,”
D.J. Bennett, R.E. Sievers, S.P. Cape, J.A. Best, A.L. Morin, C.A. Pelzmann, B.P. Quinn, L.G. Rebits, S. Evans, R.D Threadgill, D.H McAdams, In: Respiratory Drug Delivery 2008, Vol. 2, Dalby, R.N. et al. (eds.), pp. XX - YY, Davis Healthcare International Publishing, LLC, River Grove, IL.

"Stabilizing Formulations for Inhalable Powders of Live-Attenuated Measle Virus Vaccine", J.L. Burger, S.P. Cape, C.S. Braun, D.H. McAdams, J.A. Best, P. Bhagwat, P. Pathak, L.G. Rebits, R.E. Sievers, Journal of Aerosol Medicine, 21 (1) 25-34, 2008

"Method for quanitifying the sample collected by an Andersen Cascade Impactor using total organic carbon analysis", L.G. Rebits, D.J. Bennett, P.A. Bhagwat, A. Morin, R.E. Sievers, Aerosol Science 38 (2007) 1197-1206

"Fine Particle Pharmaceutical Manufacturing Using Dense Carbon Dioxide Mixed with Aqueous or Alcoholic Solutions", E.T.S. Huang, H-Y Chang, C.D. Liang, and R.E. Sievers, ACS Symp. Ser. 860, 324-338 (2003).

"Micronization of Inhalable Drugs with Liquid Carbon Dioxide at Near Ambient Conditions", R. Sievers, G. Clark, J. Villa, D. Alargov, L. Rinner, S. Cape, and E. Huang, Journal of Aerosol Medicine, 16, 213 (2003).

"Micronization of Water-Soluble or Alcohol-Soluble Pharmaceuticals and Model Compounds with a Low Temperature Bubble Dryer®", R.E. Sievers, E.T.S. Huang, J.A. Villa, G. Engling,and P. Brauer, Journal of Supercritical Fluids, 26, 9-16 (2003).

"Dry Powders of Stable Protein Formulations from Aqueous Solutions Prepared Using Supercritical CO2-Assisted Aerosolization," S.P. Sellers, G.S. Clark, R.E. Sievers, and J.F. Carpenter, Journal of Pharmaceutical Sciences, 90(6), 785-797 (2001).

"Supercritical and Near-critical Carbon Dioxide Assisted Low Temperature Bubble Drying," R.E. Sievers, P.D Milewski, S.P. Sellers, B.A. Miles, B.J. Korte, K.D. Kusek, G.S. Clark, B. Mioskowski, and J.A. Villa, Industrial and Engineering Chem. Research, 39, 4831-4836 (2000).

"Formation of Aqueous Small Droplet Aerosols Assisted by Supercritical Carbon Dioxide," R.E. Sievers, U. Karst, P.D. Milewski, S.P. Sellers. B.A. Miles, J.D. Schaefer, C.R. Stoldt, and C.Y. Xu, Aerosol Science and Technology, 30, 3-15 (1999).




Pure Appl. Chem., Vol. 73, No. 8, pp. 1299–1303, 2001. © 2001 IUPAC Low-temperature manufacturing of fine pharmaceutical powders with supercritical fluid aerosolization in a Bubble Dryer®